relationship between serum leptin, ghrelin and dietary macronutrients in women with polycystic ovary syndrome
نویسندگان
چکیده
background: polycystic ovary syndrome (pcos) is the most common endocrinopathy in women. it may involve an impairment in physiologic regulation of leptin and ghrelin. there is limited, controversial data on the relation of dietary components with leptin and ghrelin in pcos, so the current study has been conducted to explore the effects of different macronutrients on serum levels of leptin and ghrelin in pcos and healthy subjects. materials and methods: in this case-control study, we randomly choose 30 pcos patients and 30 healthy age and body mass index (bmi) matched controls. intake of macronutrients [protein, total fat, saturated, monounsaturated and polyunsaturated fatty acids (pufa), carbohydrate, dietary fiber] and energy were assessed using 3-day, 24-hour food recall and food frequency questionnaires (ffq). fasting hormonal status was measured for each participant. results: pcos women had higher levels of serum leptin, insulin, testosterone, and luteinizing hormone (lh), whereas sex hormone-binding globulin (shbg) was lower compared to healthy women. there was no significant difference in mean ghrelin concentrations between the groups. among pcos women, independent of bmi and total energy intake, we observed an inverse association between leptin concentration and total dietary fat (β=-0.16, p<0.05) and saturated fatty acid (sfa) intake (β=-0.58, p<0.05). this relationship was not seen in the healthy subjects. there was no significant association between ghrelin and macronutrients in pcos and healthy participants. conclusion: certain habitual dietary components such as fat and sfa may decrease serum leptin, whereas ghrelin is not influenced by these in pcos women. more studies are needed to better clarify the effects of dietary macronutrients on serum leptin and ghrelin.
منابع مشابه
Relationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Women with Polycystic Ovary Syndrome
Background Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. It may involve an impairment in physiologic regulation of leptin and ghrelin. There is limited, controversial data on the relation of dietary components with leptin and ghrelin in PCOS, so the current study has been conducted to explore the effects of different macronutrients on serum levels of leptin and gh...
متن کاملRelationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Women with Polycystic Ovary Syndrome
BACKGROUND Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. It may involve an impairment in physiologic regulation of leptin and ghrelin. There is limited, controversial data on the relation of dietary components with leptin and ghrelin in PCOS, so the current study has been conducted to explore the effects of different macronutrients on serum levels of leptin and gh...
متن کاملSerum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric,Metabolic, and Endocrine Parameters
متن کامل
The comparison of dietary intake of macronutrients in polycystic ovary syndrome with and without metabolic syndrome
Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. The prevalence of PCOS among Iranian women is 14.6% based on the Rotterdam definition. PCOS can increase the risk of chronic metabolic complications. Metabolic syndrome (MetS) is one of the most important of them. Insulin resistance is fundamental in PCOS and MetS pathophysiology. MetS ...
متن کاملSerum leptin concentrations in women with polycystic ovary syndrome.
The role of gonadotropins, androgens, and insulin in the regulation of circulating leptin levels is obscure. In order to clarify the relationships of these parameters we studied serum leptin levels in 19 healthy control subjects and in 35 hyperandrogenic and hyperinsulinemic patients with polycystic ovary syndrome (PCOS). Serum leptin concentrations did not differ significantly between PCOS pat...
متن کاملAssociation between Follicular Fluid Leptin and Serum Insulin Levels in Nonoverweight Women with Polycystic Ovary Syndrome
AIMS We evaluated the links between leptin and visfatin levels and fertilization rates in nonoverweight (NOW) women with PCOS (NOW-PCOS) from Apulia undergoing in vitro fertilization/embryo transfer (IVF). MATERIALS AND METHODOLOGY We recruited 16 NOW women with PCOS (NOW-PCOS) and 10 normally ovulating NOW women (control-NOW). All women underwent IVF. Androgens, 17- β -estradiol (17 β -E2), ...
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عنوان ژورنال:
international journal of fertility and sterilityجلد ۹، شماره ۳، صفحات ۳۱۳-۳۲۱
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